Endocrine Abstracts

GnRH acts via G-protein coupled receptors to stimulate phospholipase C. This activates protein kinases C, driving the activation of extracellular signal regulated kinases (ERKs) that mediates transcriptional effects of GnRH. GnRH is secreted in pulses that cause rapid, transient and reproducible ERK activation (1). ERK response kinetics dictate biological consequences in many systems and, although GnRH-mediated ERK activation has been thoroughly explored, little is known about...